Quatrefolic – Direct 5MTHF for pregnant women

Quatrefolic is the most popular type of folate among pregnant women today due to its many advantages over other forms of folate. So what are these differences? Let’s find out with Khoi Nguyen through the article below!

1. Folic acid role for pregnant women

The neural tube is a small band of tissue that then coils its length to form a tube, which will later develop into the brain and spinal cord. If this process takes place at the wrong time, the neural tube of the fetus will not close completely and will later create defects for the baby: spina bifida, craniocervical defect, …

Folic acid is a B vitamin that plays an important role in hematopoiesis and DNA replication. Folic acid has been studied to prevent neural tube defects by up to 70%. Therefore, this is a very important substance, which should be supplemented by the pregnant mother at the right time  for the normal and healthy development of the fetus.

Neural tube defects

2. Generations of folic acid

Different forms of folic acid, when entering the body, must undergo absorption and metabolism, becoming the active form 5-Methyltetrahydrofolate (5-MTHF). This is the only form that can cross the blood-brain barrier.
Currently, the market has had 4 generations of folic acid
Generation 1 – Folate from food: can be found in green vegetables, fruits, animal liver, egg yolk, …
Generation 2 – Synthetic folic acid: found in dietary supplements or multivitamin products. Folic acid does not yet have co-enzyme activity, it must be reduced to convert to the active form.
Generation 3 – Calcium salt of 5-MTHF: this is the only folic acid derivative on the market that penetrates the cell wall without further metabolism.
Generation 4 – Quatrefolic: is the latest folic acid, which improves the stability and solubility of calcium salts.


3. Quatrefolic

Quatrefolic is a form of folic acid developed by Gnosis by Lesaffre, whose molecular formula is the glucosamine salt of (6S)-5-methyltetrahydrofolate. The formula has been patented by the company since 2008.

Advantages of Quatrefolic

Quatrefolic is a superior product compared to previous generations of folic acid with long-term stability, high water solubility, enhanced bioavailability and safety during use.
Quatrefolic provides the active form of folic acid in the body, so when used, Quatrefolic does not need to go through complicated metabolic stages, but can participate in the body’s metabolic reactions.
Quatrefolic - 5MTHF
Folic acid metabolism


When comparing the pharmacokinetics of Quatrefolic with the calcium salt form of 5-MTHF and the synthetic form of folic acid, Quatrefolic showed the highest absorption concentration and the highest AUC compared with the other two forms. This demonstrates that Quatrefolic is the most bioavailable form of folic acid.

Quatrefolic - 5MTHF
Comparison of the bioavailability of the different forms of folic


Water solubility plays a very important role in the absorption of active ingredients into the body. The higher the solubility, the better the active substance is absorbed through the mucosal cells to enter the circulation, thus the bioavailability will be improved. Quatrefolic is 100 times more soluble than the calcium salt form of 5-MTHF. This could therefore explain why the bioavailability of Quatrefolic is superior to that of older generations.

Quatrefolic - 5MTHF
Comparison of the solubility of Quatrefolic with calcium salts (3rd generation folic acid)

Nutristill 90 is a supplementary product imported by Khoi Nguyen Medical Import-Export Co., Ltd directly from Italy. The product contains many vitamins and minerals, especially Quatrefolic with high content, to help provide enough nutrients for pregnant women and fetuses during pregnancy with only 1 tablet per day. You can find more detailed information about the product here